Vapreotide (acetate)

中文名	Vapreotide (acetate)
英文名	Vapreotide (acetate)
英文别名	RC160 acetate RC 160 acetate BMY41606 acetate BMY 41606 acetate BMY-41606 acetate VAPREOTIDE ACETATE Vapreotide (acetate) Vapreotide (RC160) acetate
CAS	849479-74-9
化学式	C59H74N12O11S2
分子量	1191.43
熔点	176-180°C
溶解度	乙酸 (微溶) 、甲醇 (微溶)
存储条件	Hygroscopic, Refrigerator, under inert atmosphere
稳定性	吸湿性
外观	固体
颜色	White to Off-White
体外研究	Vapreotide attenuates the Substance P (SP)-triggered intracellular calcium increases and NF-κB activation in a dose-dependent manner. Vapreotide also inhibits SP-induced IL-8 and MCP-1 production in HEK293-NK1R and U373MG cell lines. Vapreotide inhibits HIV-1 infection of human MDM in vitro , an effect that is reversible by SP pretreatment. Vapreotide significantly inhibits GH-, PRL, and/or alpha-subunit release by human GH-secreting pituitary adenoma cells in concentrations as low as 10 -12 -10 -14 M. Vapreotide inhibits GH release with an IC 50 of 0.1 pM. Vapreotide exhibits moderate-to-high affinities for SSTR2, -3, and -5 (IC 50 =0.17, 0.1 and 21 nM, respectively) and low affinity for SSTR1 and -4 (IC 50 =200 and 620 nM, respectively). RC-160 inhibits serum-induced proliferation of CHO cells expressing SSTR2 and SSTR5 (EC 50 =53 and 150 pM, respectively).
体内研究	In cirrhosis, bleeding by rupture of oesophagogastric varices is a severe complication of portal hypertension. The acute administration of vapreotide to rats decreases collateral circulation blood flow while chronic administration attenuated its development. Tumor volumes and weights are reduced by about 40% by RC-160 by s.c. injections at doses of 100 μg/day/animal. Vapreotide can inhibit the growth of androgen-independent prostate cancer when the therapy is started at an early stage of tumor development.

Vapreotide (acetate) - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	0.839 ml	4.197 ml	8.393 ml
5 mM	0.168 ml	0.839 ml	1.679 ml
10 mM	0.084 ml	0.42 ml	0.839 ml
5 mM	0.017 ml	0.084 ml	0.168 ml

最后更新：2024-01-02 23:10:35

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CAS: 849479-74-9
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CAS: 849479-74-9
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产品名: Vapreotide (acetate) 去供应商网站查看询盘
CAS: 849479-74-9
产地: 上海
规格: 98%
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